If you have been reading about circadian clock and want a single page that covers the useful parts, this is it: definitions, context, how it is studied, and the questions that come up repeatedly.
Updated 2026-05-04. Numbers and descriptions here follow the published literature rather than marketing material.
REV-ERB proteins help regulate daily cycles in gene expression, including genes tied to lipid and glucose metabolism. SR9009 binds these receptors and alters their activity in cell and animal experiments. Consequences observed in rodents include changes in skeletal muscle oxidative capacity, blood lipid levels, and exercise performance. The precise chain from receptor occupancy to whole-body effects is still an active area of study. Human responses cannot be assumed from rodent data.
Most published work on SR9009 consists of preclinical studies. It is widely sold as a research chemical, a category that does not imply safety, efficacy, or pharmaceutical-grade quality. Sports anti-doping organizations have listed SR9009 as a prohibited substance, and its presence in an athlete sample can lead to sanctions. Legal status differs by country; in several jurisdictions it is not approved for human consumption and may be treated as an unapproved new drug.
The mechanism of action involves binding to REV-ERB receptors and recruiting corepressor complexes, which represses target gene transcription. This contrasts with many nuclear receptor agonists that activate transcription. Downstream effects may include changes in autophagy, mitochondrial biogenesis, and lipid handling, but the precise pathways remain an active area of study. Whether these molecular events translate into meaningful physiological effects in humans is unresolved. Most evidence comes from cultured cells and rodent models rather than human participants.
SR9009 is a synthetic small molecule developed as an agonist of the nuclear receptors REV-ERBα (NR1D1) and REV-ERBβ (NR1D2). These receptors help regulate circadian rhythms and metabolic gene expression. In cell and animal studies, SR9009 alters transcription of genes involved in lipid metabolism, inflammation, and mitochondrial function. It is not an approved medicine, and its pharmacological profile in humans remains largely uncharacterized. The compound is frequently discussed in the context of circadian biology and metabolic research rather than clinical use.
Preclinical reports have linked SR9009 to improved endurance and altered energy expenditure in rodents. Such findings have prompted interest in whether REV-ERB activation can influence skeletal muscle metabolism. However, the reported effects depend on dose, route, and experimental model, and replication across laboratories is limited. Human trials have not established comparable outcomes, so claims about exercise performance remain speculative. The absence of controlled human data is a central limitation in interpreting these observations.
| Property | Value | Notes |
|---|---|---|
| Common name | SR9009 | Also referred to as Stenabolic in non-scientific contexts. |
| Chemical class | Synthetic small molecule | Not a steroid or peptide hormone. |
| Receptor target | REV-ERBα and REV-ERBβ | Nuclear receptor agonist in preclinical studies. |
| Development status | Investigational | No approved human therapeutic indication. |
| Regulatory attention | Prohibited in sport | Listed by anti-doping authorities. |
Several misconceptions surround SR9009. It is often described as a SARM, a steroid, or an exercise pill, but its known target is the REV-ERB receptor family. Rodent studies have examined exercise capacity and metabolic markers, yet human outcomes remain unproven. Oral bioavailability appears low in animals, and human pharmacokinetics are not well characterized. Online products may contain impurities or different compounds, so identity and purity testing are important for research use.
Analytical chemists detect SR9009 with liquid chromatography-tandem mass spectrometry, commonly abbreviated LC-MS/MS. Sample preparation may involve protein precipitation, liquid-liquid extraction, or solid-phase extraction before analysis. Laboratories can target the parent compound or its metabolites, depending on the matrix and the purpose of testing. Anti-doping methods require sensitive and specific assays because concentrations in biological samples can be low. Reference standards and validated methods are essential for reliable identification and quantification.
A small randomized controlled trial from 2017 confirms the nutritional balance of MRE eaten-in-whole using blood tests. The military has experimented with new assault ration prototypes, such as the First Strike Ration and the HOOAH! Bar, designed with elite or specialized forces in mind. Lighter than the typical MRE, they require no preparation and allow service members to eat them while traveling. In July 2009, 6,300 dairy shake packets of varying flavors were recalled due to evidence of Salmonella contamination.
An insulin pump is a medical device used for the administration of insulin in the treatment of diabetes mellitus, also known as continuous subcutaneous insulin therapy (CSII = Continuous Subcutaneous Insulin Infusion). The device configuration may vary depending on design. A traditional pump includes:
=== Effects on physiological development === In general, androgens such as testosterone promote protein synthesis and thus growth of tissues with androgen receptors. Testosterone can be described as having anabolic and androgenic (virilising) effects, though these categorical descriptions are somewhat arbitrary, as there is a great deal of mutual overlap between them. The relative potency of these effects can depend on various factors and is a topic of ongoing research. Testosterone can either directly exert effects on target tissues or be metabolized by 5α-reductase into dihydrotestosterone (DHT) or aromatized to estradiol (E2). Both testosterone and DHT bind to an androgen receptor; however, DHT has a stronger binding affinity than testosterone and may have more androgenic effect in certain tissues at lower levels.
Camurus AB (publ) is a Swedish research-based pharmaceutical and biotechnology company specialising in the commercialization of medicines for treating serious and chronic diseases. Established in 1991 and based in the southern university city of Lund, in the Medicon Valley region, the company is listed on Nasdaq Stockholm, Mid Cap. Camurus was founded by scientists in biophysical, food, and pharmaceutical chemistry with expertise in lipid phase structures. The company provides nanoscale drug-delivery systems for development of high-value therapeutics.
Compactituberculate - The dome-shaped tops of the shell units form a dense covering of nodes on the surface of the eggshell. This type of ornamentation is most commonly seen in megaloolithids. Sagenotuberculate - The nodes and ridges form a netlike pattern interspersed with pits and grooves. Dispersituberculate - Scattered nodes. This ornamentation is seen on the poles of elongated eggs, which may have allowed accumulations CO2 at the poles to escape between the nodes. Lineartuberculate - Ridges, and chains of ridges and nodes form lines parallel to the long axis of the egg. Ramotuberculate - Irregular chains of nodes, typically found as a transition between the lineartuberculate midsection and dispersituberculate ends of elongated eggs. Anastomotuberculate - Ridges similar to lineartuberculate, but instead form wavy, branching, or anastomosing patterns resembling the water ripple marks in sand.
Sources: en.wikipedia.org
== Structure == VEGFR-2 are a part of the VEGF family. The other receptors in the family are VEGFR-1 and VEGFR-3. These receptors are a type of transmembrane kinase receptors and have similar structure. They have an extracellular part that is made up of an N-terminus signal and a 7 immunoglobulin-like domain. The intracellular part of the receptor consists of a juxtamembrane (the tyrosine kinase domain), which is divided to proximal and distal kinase domains and a C-terminus tail.
== Experimental chemistry == The isotopes 284Nh, 285Nh, and 286Nh have half-lives long enough for chemical investigation. From 2010 to 2012, some preliminary chemical experiments were performed at the JINR to determine the volatility of nihonium. The isotope 284Nh was investigated, made as the daughter of 288Mc produced in the 243Am+48Ca reaction. The nihonium atoms were synthesised in a recoil chamber and then carried along polytetrafluoroethylene (PTFE) capillaries at 70 °C by a carrier gas to the gold-covered detectors. About ten to twenty atoms of 284Nh were produced, but none of these atoms were registered by the detectors, suggesting either that nihonium was similar in volatility to the noble gases (and thus diffused away too quickly to be detected) or, more plausibly, that pure nihonium was not very volatile and thus could not efficiently pass through the PTFE capillaries. Formation of the hydroxide NhOH should ease the transport, as nihonium hydroxide is expected to be more volatile than elemental nihonium, and this reaction could be facilitated by adding more water vapour into the carrier gas. It seems likely that this formation is not kinetically favoured, so the longer-lived isotopes 285Nh and 286Nh were considered more desirable for future experiments. A 2017 experiment at the JINR, producing 284Nh and 285Nh via the 243Am+48Ca reaction as the daughters of 288Mc and 289Mc, avoided this problem by removing the quartz surface, using only PTFE.
In March 2016, Taco Bell introduced private beta testing of an artificial intelligence bot on the messaging platform Slack designed to take orders of select menu items from local Taco Bell locations and have the orders delivered. Taco Bell planned to have a wider roll-out of this functionality in the coming months. Previously, Taco Bell's hot sauces were only available in packets at the chain itself. In February 2014, Taco Bell made its hot sauces available at grocery stores, sold in bottles. These would be followed by further grocery store products including chips in May 2018 and shredded cheese in 2019. In September 2016, Taco Bell opened a pop-up in New York City in the SoHo, Manhattan area called the Taco Bell VR Arcade. Taco Bell and VR fans could demo PlayStation VR, games, and food. In 2016, Taco Bell debuted a modular restaurant constructed from five reclaimed shipping containers at the South by Southwest (SXSW) festival in Austin, Texas. Following its successful reception, the structure was permanently relocated to South Gate, California, where it commenced operations as a standard franchise location in 2017. The restaurant features Taco Bell's full menu, with outdoor seating, a walk-up window, and a drive-thru, but no indoor seating unlike regular Taco Bell locations. Taco Bell announced plans in November 2017 to open 300 more urban and Cantina-style locations by 2022, with 50 to be located about New York City's five boroughs. In 2019, Taco Bell opened a pop-up hotel called "The Bell: A Taco Bell Hotel and Resort" for one weekend in August.
== The TRAIL receptors as a drug target == In clinical trials only a small proportion of cancer patients responded to various drugs that targeted TRAIL death receptors. Many cancer cell lines develop resistance to TRAIL and limits the efficacy of TRAIL-based therapies.
Prior to 1919 only atomic weights averaged over a very large number of atoms was available. In that year, Francis Aston built the first mass spectrograph, an improved form of a device built by J. J. Thomson to measure the deflection of positively charged atoms by electric and magnetic fields. Aston was then able to separate the isotopes of many light elements including neon, 20Ne and 22Ne. Aston discovered the isotopes matched William Prout's whole number rule: the mass of every isotope is a whole number multiple of hydrogen. Significantly, the one exception to this whole number rule was hydrogen itself, which had a mass value of 1.008. The excess mass was small, but well outside the limits of experimental uncertainty. Aston and others realized this difference was due to the binding energy of atoms. When a number of hydrogen atoms are bound into an atom, that atom's energy must be less than the sum of the energies of the separate hydrogen atoms. That lost energy, according to the mass-energy equivalence principle, means the atomic mass will be slightly less than the sum of the masses of its components. Aston's work on isotopes won him the 1922 Nobel Prize in Chemistry for the discovery of isotopes in a large number of non-radioactive elements, and for his enunciation of the whole number rule.
Sources: en.wikipedia.org
==== Iraq War ==== Hitchens employed the term "Islamofascist" and supported the Iraq War, causing his critics to consider him a "neoconservative". Hitchens, however, refused to embrace this designation, insisting, "I'm not any kind of conservative". In 2004, Hitchens stated that neoconservative support for US intervention in Iraq convinced him that he was "on the same side as the neo-conservatives" when it came to contemporary foreign policy issues, and characterized himself as an unqualified "supporter of Paul Wolfowitz." He referred to his associations as "temporary neocon allies". In this period he opined that "the Bush administration [...] has redefined the lazy term 'conservative' to mean someone who is impatient with the status quo." In the years after the fatwa issued against Salman Rushdie in response to his novel The Satanic Verses, Hitchens became increasingly critical of what he called "excuse making" on the left. At the same time, he was attracted to the foreign policy ideas of some on the Republican-right that promoted pro-liberalism intervention, especially the neoconservative group that included Paul Wolfowitz. Around this time, he befriended the Iraqi dissident and businessman Ahmed Chalabi. Hitchens argued the case for the Iraq War in a 2003 collection of essays entitled A Long Short War: The Postponed Liberation of Iraq, and participated in public debates on the topic with George Galloway, Scott Ritter, and his brother Peter Hitchens.
=== Scientific journal articles === Holick, MF (2007). "Vitamin D deficiency". N Engl J Med. 357 (3): 266–81. doi:10.1056/NEJMra070553. PMID 17634462. S2CID 18566028. Holick, MF (2006). "Resurrection of vitamin D deficiency and rickets". J Clin Invest. 116 (8): 2062–72. doi:10.1172/JCI29449. PMC 1523417. PMID 16886050. Pietras, SM; Obayan, BK; Chai, MH; Holick, MF (2010). "Vitamin D2 treatment for vitamin D deficiency and insufficiency for up to 6 years". Arch Intern Med. 169 (19): 1806–8. doi:10.1001/archinternmed.2009.361. PMID 19858440. Biancuzzo, RM; Young, A; Bibuld, D; Cai, MH; Winter, RM; Klein, EK; Ameri, A; Reitz, R; Salameh, W; Chen, TC; Holick, MF (2010). "Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults". Am J Clin Nutr. 91 (6): 1621–6. doi:10.3945/ajcn.2009.27972. PMC 2869510. PMID 20427729. Holick, MF; Binkley, NC; Bischoff-Ferrari, HA; Gordon, CM; Hanley, DA; Heaney, RP; Murad, MH; Weaver, CM; et al. (2011). "Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline". J Clin Endocrinol Metab. 96 (7): 1911–30. doi:10.1210/jc.2011-0385. PMID 21646368.
Poppy tea is a herbal tea infusion brewed from poppy straw or seeds of several species of poppy. The species most commonly used for this purpose is Papaver somniferum, which produces opium as a natural defense against predators. In the live flower, opium is released when the surface of the bulb, called the seed pod, is pierced or scraped. For the purpose of the tea, dried pods are more commonly used than the pods of the live flower. The walls of the dried pods contain opiate alkaloids, primarily consisting of morphine and codeine. The tea is consumed for its narcotic effect, and in small amounts for analgesic, anti-diarrheal, and sedative effects. It has also been known to be used as a method of relieving withdrawal symptoms. Use of such preparations originated in parts of Central and Eastern Europe, the Levant and Near East, and Central and South Central Asia millennia ago. The flowers of the poppy plant have long been used as a painkiller for soothing mild aches and pains (e.g. toothache, earache and sore throat), a mild sedative/relaxant, an expectorant for treating catarrh and coughs, as a digestive, and even for reducing the appearance of wrinkles and in lipsticks. This tea is depicted both in Asian literature, Western literature, and is depicted as being available in opium dens.
have disease progression during or following platinum-containing chemotherapy. have disease progression within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy. On 16 February 2018, the Food and Drug Administration approved durvalumab for patients with unresectable stage III non-small cell lung cancer (NSCLC) whose disease has not progressed following concurrent platinum-based chemotherapy and radiation therapy.
Within Contact and Special Circumstances, there are also inner circles that can take control in crises, somewhat contradictory to the ideal notions of democratic and open process the Culture espouses. Contact and Special Circumstances may suppress or delay the release of information, for example to avoid creating public pressure for actions they consider imprudent or to prevent other civilisations from exploiting certain situations. In dealing with less powerful regressive civilisations, the Culture usually intervenes discreetly, for example by protecting and discreetly supporting the more liberal elements, or subverting illiberal institutions. For instance, in Use of Weapons, the Culture operates within a less advanced illiberal society through control of a business cartel which is known for its humanitarian and social development investments, as well as generic good Samaritanism. In Excession, a sub-group of Minds conspires to provoke a war with the extremely sadistic Affront, although the conspiracy is foiled by a GSV that is a deep cover Special Circumstances agent. Only one story, Consider Phlebas, pits the Culture against a highly illiberal society of approximately equal power: the aggressive, theocratic Idirans. Though they posed no immediate, direct threat to the Culture, the Culture declared war because it would have felt useless if it allowed the Idirans' ruthless expansion to continue. The Culture's decision was a value-judgement rather than a utilitarian calculation, and the "Peace Faction" within the Culture seceded.
Sources: en.wikipedia.org
It is a synthetic compound studied as an agonist of REV-ERB nuclear receptors. It is not an approved medicine and has mainly been examined in laboratory and animal research.
No. It is a small molecule that binds nuclear receptors involved in circadian regulation. Its classification differs from anabolic steroids or peptide hormones.
Published human clinical trial data are lacking. Most safety and activity information comes from preclinical models, so effects in people remain uncertain.
It is a synthetic compound that acts as an agonist at REV-ERBα and REV-ERBβ. It is used mainly as a research chemical to study circadian and metabolic pathways. It is not approved for human therapeutic use.